Investigating Language Processing in the Brain

Cross Site 1

Lesion overlay map for a group of 71 participants with aphasia
Cross Site

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White matter regions predictive of language performance
Cross Site

NU Slide1 Copy

fMRI activation for passive sentences > reversed speech (red) and reversed speech > passive sentences (blue) in a group of healthy individuals
NU Project 3

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Meta-analysis of studies on sentence processing showing regions of significant activation for non-canonical vs. canonical sentences in healthy individuals
NU Project 3

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Task modulated connectivity in (A) healthy and (B) aphasic individuals
BU Project 1

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fMRI activation for pictures > scrambled pictures in a group of healthy individuals
BU Project 1

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Left vOTC area where local heterogeneity of BOLD spelling response to training words increases pre to post treatment
JHU Project 2

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Resting state connectivity of the visual word form area
JHU Project 2

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Northwestern University’s Aphasia and Neurolinguistics Research

The Aphasia and Neurolinguistics Research Laboratory investigates the effect of sentence-level treatment on language and brain recovery. Participants receive treatment focused on complex sentence structures, with recovery of untrained less complex sentences an expected outcome of treatment.

P.I. Cynthia K. Thompson, Ph.D

Boston University’s Aphasia Research Laboratory

The primary goal of the Boston University’s Aphasia Research Laboratory is to study the recovery of naming ability. Treatment focuses on naming objects or things within semantic categories based on their meaning and the features that connect them.

P.I. Swathi Kiran, Ph.D., CCC-SLP & David Caplan, M.D., Ph.D.

Johns Hopkins University’s Cognitive and Brain Sciences Laboratory

The CogNeuro Lab at John Hopkins University is primarily concerned with studying the effects of treatment of spelling abilities using a cognitive neuropsychologically based approach. Treatment focuses on spelling selected sets of words, with expected improvement of trained words, as well as related words with overlapping spellings.

P.I. Brenda Rapp, Ph.D.

About Us

Welcome to the Center for the Neurobiology of Language Recovery (CNLR). CNLR is supported by a $12 million National Institutes of Health (NIH), National Institute of Deafness and other Communication Disorders (NIDCD) Clinical Research Center grant. The Center is uniquely focused on research investigating how language recovers in aphasia, how treatment affects recovery, how the neural networks for language reorganize during recovery, and what factors predict language recovery.

The unprecedented Center brings together top researchers in the field to study language recovery in aphasia. The Director of CNLR, Cynthia, K. Thompson, Ph.D., is joined by Todd B. Parrish, Ph.D. at Northwestern University, as well as David Caplan, M.D., Ph.D. from Harvard University, Swathi Kiran, Ph.D., CCC-SLP from Boston University, and Brenda Rapp, Ph.D. from Johns Hopkins University.  The Center focuses its research efforts on language recovery in stroke-induced, chronic aphasia. Currently, our research investigates three different types of aphasia: agrammatism (sentence processing deficits), dysgraphia (spelling and writing deficits), and anomia (naming deficit).

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