Study Design

Research

 
Study Design

 

CNLR supports three projects; each project investigates a different language deficit in people with aphasia while maintaining a level of consistency across studies. All three projects recruit individuals who acquired aphasia following a stroke. Each potential participant completes a language evaluation to determine eligibility for any of CNLR’s current projects.

 

When participants enter the study a language assessment (Pre-Assessment) is administered by one of our clinicians and 2–3 MRI scans are obtained. This is done to determine cognitive/language abilities and to measures how the brain processes language. Then, participants are randomly assigned to either the Treatment Group or the Control Group. The Control Group serves as a comparison to the Treatment Group. Data obtained from participants in the Control Group documents natural recovery of language in chronic, stroke-induced aphasia. Participants assigned to the Control Group are eligible to participate in the Treatment Group, following completion of the control phase of the study.

 

Participants assigned to the Treatment Group

  • Enroll in treatment, which is provided twice a week for three months (0-3 months of the study).
  • Participate in post-treatment language testing and MRI scans at the end of the 3-month treatment period (Post-Assessment). This is done to evaluate changes in language and brain function following treatment (compared to baseline performance).
  • Participate in follow-up language testing and MRI scans (Follow-up Assessment), after another three-month period in which treatment is not provided. This is done to see if treatment effects are maintained.

 

Participants assigned to the Control Group

  • Do not receive treatment for the first three months (0-3 months of the study).
  • Participate in language testing and MRI scans at the end of the three-month period (Post-Assessment). This is done to evaluate natural recovery of language and brain function (compared to baseline performance).
  • Participate in language testing and MRI scans following another three-month period (Follow-up Assessment). This is done to evaluate natural recovery of language and brain function (compared to baseline and 3-months Post-Assessment performance).
  • May by enrolled in the Treatment Group and receive treatment of the same type and on the same schedule as participants who begin the study in the Treatment Group.

 

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